Magnolia officinalis is the premier herb in the Traditional Chinese system of Medicine for reducing stress & anxiety while promoting the activities of the parasympathetic (rest & digest) nervous system.
Magnolia is one tool that no herbalist should be without. Most effective in times of stress or anxiety, Magnolia has been shown to behave as a positive allosteric modulator of the benzodiazepine site which reduces the amount of GABA needed to activate the GABA(A) receptor. Magnolia also increases the expression of the alpha GABA receptors & has barbiturate type effects. Outside of the potent GABAnergic effects, Magnolia may reduce the secretion of adrenaline from the adrenal glands, antagonize NMDA receptors thus reducing seizure threshold, & enhance cholinergic neurotransmission, specifically of the muscarinic subtype, strengthening the parasympathetic nervous system.
tonic, sedative, hypnotic, analgesic, anticonvulsant, antispasmodic, anti-inflammatory, antidepressant, adaptogenic, antioxidant, neuroprotection